Andrij Tolmachev

Andrij Tolmachev

Director of Chemico-Biological Center

Engineer, Junior Researcher, Senior Researcher, Leading Researcher
²nstitut of Organic Chemistry National Academy of Science of Ukraine, Kyiv (Ukraine)

Director of Chemico-Biological Center
Taras Shevchenko National University of Kyiv, Kyiv (Ukraine)


Organic and Bioorganic Chemistry

Research Fields:

Previous and Current Research

Group leader : Dr. Chem. Sci., Prof. ANDRIJ TOLMACHEV

Scientific staff specializes in the development of new approaches to search, synthesis and further optimization of physiologically active substances.

  • Improvement and implementation of methods for the analysis of materials and environmental objects, methods for studying the structure, physical, physico-chemical and biological characteristics and parameters of substances and materials;
  • Development of methods and technologies of new substances and materials for the purpose of experimental industrial and industrial production in the world markets competitive products;
  • Among the objects of study - heterocyclic compounds such classes:
  • Heterocyclic hydrazide, amines and amides;
  • Heterocyclic compounds containing heteroatoms of phosphorus, silicon, etc;
  • New fluorocontaining compounds with unique biological properties;
  • Unique heterocyclic and heteroaromatic sulfochlorides
  • Hetaryl and enamine host compound

The compounds were characterized by NMR spectroscopy on different cores proved their identity and characteristics of chemical purity analytical methods and preparative LCMS methods

Selected Publications

Ryabukhin S. V. Panov D. M. Grygorenko O. O Tolmachev. A.O.
Approach to the Library of 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a Three-Component Condensation
ACS Comb. Sci., 2012, Vol. 14, ¹ 12, pp. 631-635

Stepaniuk O.; Matvienko V.; Kondratov I; Shishkin O.; Volochnyuk D.; Mykhailiuk P; Tolmachev. A.O.
Regioselective Reactions of Ethyl (4,5-Dihydrofuran-3-yl)-2-oxoacetate and Ethyl 2-(3,4-Dihydro-2H-pyran-6-yl)-2-oxoacetate with 1-Unsubstituted Aminoazoles
Synthesis 2012, Vol. 44, Issue 6, pp. 895-902.

Tkachenko A.; Radchenko D.; Mykhailiuk P; Shishkin O.; Komarov.I Tolmachev. A.O.
Exploiting the Addition of Trimethyl(trifluoromethyl)silane to Functionalized N-Benzylimines for the Preparation of Two Novel x-Trifluoromethyl x-Amino Acids
Synthesis 2012, Vol. 44, Issue 6, pp. 903-908

Yarmolchuk V.; Bezdudny A.; Tolmacheva N.; Lukin, Oleg; Boyko A.; Chekotylo A; Mykhailiuk P.,Tolmachev. A.O.
An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl) cyclopropylamine
Synthesis 2012, Vol. 44, Issue 8, pp. 1152-1154

B. Demydchuk, K. Kondratyuk, A. Korniyenko, V. Brovarets, RVasylyshyn, O.Lukin, Tolmachev. A.O.
Chlorotrimethylsilane Mediated Synthesis of Functionalized (2-Hydroxyphenyl)(pyrido[1,2-a]benzimidazol-2-yl) methanones
Synth. Commun. 2012, Vol. 42, 687-91

Andrey Bogolubsky; Alexander Grishchenko; Anzhelika Konovets; Alexander Chuprina; Alexander Boyko; Alexey Chekotylo; Oleg Lukin, Tolmachev. A.O.
A solution-phase parallel synthesis of alkylated guanidines from thioisocyanates and amines.
Molecular Diversity , Volume 17 (3) – Aug 1, 2013, 471-477.

Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Anzhelika I. Konovets, Irina V. Sadkova, Tolmachev. A.O.
Sulfonyl Fluorides as Alternative to Sulfonyl Chlorides in Parallel Synthesis of Aliphatic Sulfonamides.
ACS Combinatorial Science vol. 16 issue 4 April 14, 2014. p. 192-197

Geraschenko O. V., Shishkin O. V., Mykhailiuk P. K., Tolmachev. A.O.
Synthesis and Functionalization of 3-Azolylquinoxalin-2(1H)-ones.
Synthesis, 2014, DOI: 10.1055/s-0033-1340983

Bogolubsky A.V., Pipko S.E., Mykhailiuk P.K., Konovets A.I., Granat D.S., Doroschuk R., Tolmachev. A.O.
Bis(2,2,2-trifluoroethyl) carbonate as a condensing agent in one-pot, parallel synthesis of unsymmetrical aliphatic ureas
Synthesis. – 2014. – Vol. 46. – P. 1778-1783.

Bogolubsky A.V., Pipko S.E., Konovets A.I., Panov D.M., Doroschuk R., Tolmachev. A.O.
One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones
Synthesis. – 2014. – Vol. 46. – P. 1765-1772.

Bogolubsky A.V., Pipko S.E., Mykhailiuk P.K., Konovets A.I., Panov D.M., Tolmachev. A.O.
A one-pot parallel reductive amination of aldehydes with heteroaromatic amines.
ACS Comb. Sci. - 2014. - Vol. 16. - P. 375–380.

Ryabukhin S. V., Granat D. S., Shivanyuk A. N., Lukin O., Tolmachev. A.O.
Synthesis of pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones
Tetrahedron Lett., 2014, Vol. 55, ¹ 10, pp. 1846-1847